Starting at: $74.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| IX03208-25 | 25ug | Starting at: $245.00 | ||
| IX03208-5 | 5ug | Starting at: $74.00 |
Starting at: $699.00
Starting at: $1,012.00
Overview
| Synonyms | brain-derived neurotrophic factor, abrineurin |
| Description | BDNF, also known as brain-derived neurotrophic factor and abrineurin, is a neurotrophin belonging to the NGF-beta family. It is expressed highly in the brain, and moderately in the heart, lung, skeletal muscle and placenta. BDNF signals through its high affinity receptor gp145/trkB to exert neurotrophic properties. It has been shown to be involved in the survival and differentiation of both the central and peripheral nervous system. Specifically, BDNF regulates synaptic transmission, axonal growth and path-finding, as well as dendritic growth and morphology. |
| Species | Human |
| Source | CHO |
| Biological Activity | ED50<4μg/ml, measured in a bioassay using C6 cells. |
| Sequence |
HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE
KVPVSKGQLK QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV CTLTIKRGR |
Properties
| Measured Molecular Weight | 12-14kDa, observed by reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Endotoxin Level | <0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human BDNF remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, human BDNF should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Note | For research use only |