Starting at: $75.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| IX03314-1 | 1mg | Starting at: $1,686.00 | ||
| IX03314-10 | 10ug | Starting at: $75.00 | ||
| IX03314-50 | 50ug | Starting at: $199.00 |
Starting at: $699.00
Starting at: $1,012.00
Overview
| Synonyms | Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2 |
| Description | Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb. However, while KGF induces proliferation and differentiation of various epithelial cells, FGF-10 promotes budding and branching morphogenesis during the multi-organ development via mesenchymal-epithelial cell interactions. FGF-10 is critical for lung and limb development, and is regulated by Shh during early development. Recombinant Human FGF-10 produced in E. coli is a single, non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-10 has a molecular mass of 19.3 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
| Accession No | O15520 |
| Source | E. coli |
| Biological Activity | ED50 < 20 ng/mL, measured by a cell proliferation assay using 4 MBr-5 cells, corresponding to a specific activity of > 5.0 × 104 units/mg. |
| Sequence |
Leu40-Ser208 (accession number: O15520)
|
Properties
| Measured Molecular Weight | 19.3 kDa, observed by reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O at 100 μg/ml. |
| Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant Human FGF-10 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human FGF-10 should be stable up to 1 week at 4°C or up to 3 months at -20°C. |
| Note | For research use only |