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GM-CSF, Human

SKU: IX02695

GM-CSF, Human

SKU: IX02695
Pricing Starting at

Starting at: $107.00

Available Options

SKUPackage SizePriceQuantityAdd to Cart
IX02695-11mgStarting at: $2,621.00
IX02695-1010ugStarting at: $107.00
IX02695-5050ugStarting at: $344.00

Associated Products

Description

Overview

Synonyms Granulocyte Macrophage Colony Stimulating Factor, CSF-2, MGI-1GM, GM-CSF, Pluripoietin-alpha, Molgramostin, Sargramostim, MGC131935, MGC138897
Description Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF), a hematopoietic growth factor, is mainly involved in granulopoiesis and monocytopoiesis. It is produced by T-cells and macrophages in response to antigens, and by endothelial cells and fibroblasts following induction of variouscytokines [1]. A monomeric protein of 127 amino acidswith six glycosylation sites and two intra disulfide bonds [2,3], glycosylated and non-glycosylated hGM-CSFs show similar biological activities [4].Other than its connection to the growth and development of granulocytes and macrophages, it is also indispensable for the proliferation of erythroid and megakaryocytic cells [5].
Recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) produced in E. coli is a non-glycosylated polypeptide. A fully biologically active molecule, rhGM-CSF has a molecular mass of 14 kDa analyzed by SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
Species Human
Source E. coli
Biological Activity ED50 < 0.5 ng/ml, measured by proliferation assay of TF-1 cells, corresponding to a specific activity of >2.0 x 106units/mg
Sequence
MAPARSPSPS   TQPWEHVNAI   QEARRLLNLS   RDTAAEMNET
VEVISEMFDL   QEPTCLQTRL   ELYKQGLRGS   LTKLKGPLTM
MASHYKQHCP   PTPETSCATQ   IITFESFKEN   LKDFLLVIPF
DCWEPVQE

Properties

Measured Molecular Weight 14 kDa, observed by SDS-PAGE.
Purity >95 % as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against 10 mM PB, pH7.0.
Reconstitution Reconstituted in ddH2O at 100μg/ml.
Endotoxin Level <1 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) remains stable up to 12 months at lower than -70°C from date of receipt. Upon reconstitution, rhGM-CSF should be stable up to 4 weeks at 4°C or up to 6 months at -20°C.
Note For research use only

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