Starting at: $107.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| IX02983-1 | 1mg | Starting at: $2,621.00 | ||
| IX02983-10 | 10ug | Starting at: $107.00 | ||
| IX02983-50 | 50ug | Starting at: $344.00 |
Starting at: $699.00
Starting at: $1,012.00
Overview
| Synonyms | Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-α |
| Description | Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is produced by a number of different cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effectors functions of granulocytes,monocytes/macrophages and eosinophils. Human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) can induce human endothelial cells to migrate and proliferate. Additionally, Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) can stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma, and adenocarcinoma cell lines. |
| Species | Human |
| Source | CHO |
| Biological Activity | ED50 < 0.2 ng/ml, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 5×106 units/mg. |
| Sequence |
APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV
EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE |
Properties
| Measured Molecular Weight | 22-28 kDa, observed by non-reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE and HPLC. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhGM-CSF should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Note | For research use only |