Starting at: $107.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| IX03121-1 | 1mg | Starting at: $2,621.00 | ||
| IX03121-10 | 10ug | Starting at: $107.00 | ||
| IX03121-50 | 50ug | Starting at: $344.00 |
Starting at: $699.00
Starting at: $1,012.00
Overview
| Synonyms | B-TCGF, CSIF, TGIF |
| Description | Interleukin-10 (IL-10), initially known as Cytokine Synthesis Inhibitory Factor (CSIF), belongs to the IL-10 family and shares more than 80% sequence homology with Epstein-Barr Virus protein BCRFI. It is produced by many immune cells, such as T-cells, macrophages, mast cells, and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. It also displays ability to suppress Antigen-Presenting Cell (APC) function. The net effect of Interleukin-10 appears to be inhibitory; however, stimulatory effects, such as stimulation of B cell maturation and antibody production, are also reported. |
| Accession No | P22301 |
| Species | Human |
| Source | CHO |
| Biological Activity | ED50 < 0.2 ng/ml, measured in a cell proliferation assay using MC/9 cells. |
| Sequence |
SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK
DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN |
Properties
| Measured Molecular Weight | 18-19 kDa, observed by reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE and HPLC. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant Human Interleukin-10 remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-10 should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Note | For research use only |