Starting at: $107.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| IX03020-1 | 1mg | Starting at: $2,621.00 | ||
| IX03020-10 | 10ug | Starting at: $107.00 | ||
| IX03020-50 | 50ug | Starting at: $344.00 |
Starting at: $699.00
Starting at: $1,012.00
Overview
| Synonyms | NC30 (Human), P600 (Murine);IL-13 (human) |
| Description | Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive. Recombinant human interleukin 13 expressed in CHO cells is glycosylated protein with molecular weight range from 25 to 45 kDa shown in non-reducing SDS-PAGE. |
| Accession No | P35225 |
| Species | Human |
| Source | CHO |
| Biological Activity | ED50 < 15 ng/ml, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7×105 units/mg. |
| Sequence |
SPGPVPPSTA LRELIEELVN ITQNQKAPLC NGSMVWSINL
TAGMYCAALE SLINVSGCSA IEKTQRMLSG FCPHKVSAGQ FSSLHVRDTK IEVAQFVKDL LLHLKKLFRE GRFN |
Properties
| Measured Molecular Weight | 25-45 kDa, observed by non-reducing SDS-PAGE. |
| Purity | > 95% as analyzed by SDS-PAGE. |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
| Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human Interleukin 13 (IL-13) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIL-13 should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
| Note | For research use only |