Starting at: $644.00
| SKU | Package Size | Price | Quantity | Add to Cart |
|---|---|---|---|---|
| 10HU-024-5M | Cryopreserved, 5.0 million cells/vial | Starting at: $644.00 | ||
| 10HU-024-10M | Cryopreserved, 10 million cells/vial | Starting at: $937.00 |
Product Description
The CD8+ T cells, also known as Cytotoxic T cells (TC cells), are a type of T cells that kill cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways. Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen, and a glycoprotein called CD8 which binds to the constant portion of the class I MHC molecule. When exposed to infected/dysfunctional somatic cells, CD8+ T cells release the cytotoxins perforin, granzymes, and granulysin, which triggers the caspase cascade and eventually leads to apoptosis. CD8+ T cells have been implicated in the pathogenesis of hepatitis B virus infection [1], arthritis [2] etc.
iXCells Biotechnologies offers CD8+ T cells isolated from normal human peripheral blood mononuclear cells (PBMCs) using positive immunomagnetic selection. > 90% of the cells are CD8+ as showed by flow cytometric analysis (Figure 1).
Figure 1. Flow cytometric analysis showed that >90% of the cells are CD8+.
Product Details
| issue | Normal human peripheral blood |
| Package Size | 5.0×106 cells/vial, 1.0×107 cells/vial |
| Purity | >90% |
| Passage Number | P0 |
| Shipped | Cryopreserved |
| Storage | Liquid nitrogen |
| Growth Properties | Suspension |
| Media | Blood Cell Culture Medium (Cat# MD-0007) |
References
[1] Iannacone, Matteo; Sitia, Giovanni; Guidotti, Luca G (2006). “Pathogenetic and antiviral immune responses against hepatitis B virus”. Future Virology 1 (2): 189–96.
[2] Subramanian S and Ramalingam K (2005). “Electron microscopic evidence on the participation Cytotoxic T Lymphocytes and Macrophages in Mtb adjuvant induced connective tissue inflammation and arthritogenesis in Rattus norvegicus”. Asian Journal of Microbiology, Biotechnology and Environmental Sciences 7 (2): 227–233.