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HC-ra Human Chondrocytes are derived from human articular cartilage of donors with rheumatoid arthritis. Rheumatoid arthritis is an inflammatory disease that is characterized by overproliferation of synovial cells and their infiltration into adjacent joint tissues, accompanied by gradual destruction of cartilage and bone erosion. Normally, chondrocytes are responsible for producing and maintaining the extracellular matrix of cartilage, but in rheumatoid arthritis cartilage, the environment is changed significantly due to inflammation and the invasion of other cells. Therefore, HC-ra can be a useful model to study the effects of those changes on chondrocyte biology. In parallel with normal HC, HC-ra can be used to investigate the differences between normal and pathological joints and evaluate potential treatment strategies.
iXCells Biotechnologies provides high quality Human Chondrocytes-Rheumatoid Arthritis (HC-ra), which are isolated from human articular cartilage of donors with rheumatoid arthritis and cryopreserved at P1, with >0.5 million cells in each vial. These HC-ra are positive for aggrecan after differentiation and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HC-ra can further expand for 10 population doublings in Chondrocyte Medium (Cat# MD-0040) under the condition suggested by iXCells Biotechnologies.
|Tissue||Human articular cartilage of donors with rheumatoid arthritis|
|Package Size||0.5 millioncells/vial|
|Media||Chondrocyte Medium(Cat# MD-0040)|