Description
Overview
Synonyms | T-cell growth factor (TCGF), Aldesleukin |
Description | Interleukin-2 (IL-2) is a Oglycosylated, four α-helix bundle cytokine that has potent stimulatory activity for antigen-activated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. |
Accession No | P60568 |
Species | Human |
Source | HEK 293 |
Biological Activity | ED50 < 2ng/ml, measured in a cell proliferation assay using CTLL-2 cells. |
Sequence |
00001 APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML
00041 TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL 00081 RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR 00121 WITFCQSIIS TLT |
Properties
Measured Molecular Weight | 15~16 kDa, observed by reducing SDS-PAGE. |
Purity | > 95% as analyzed by SDS-PAGE. |
Formulation | Lyophilized after extensive dialysis against PBS. |
Reconstitution | Reconstituted in ddH2O or PBS at 100 μg/ml. |
Endotoxin Level | < 0.2 EU/μg, determined by LAL method. |
Storage | Lyophilized recombinant Human Interleukin-2 (IL-2) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human Interleukin-2 (IL-2) should be stable up to 1 week at 4°C or up to 2 months at -20°C. |
Note | For research use only |